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1 Then I being grieved did weep, and in my sorrow prayed, saying, 2 O Lord, thou art just, and all thy works and all thy ways are mercy and truth, and thou judgest truly and justly for ever. 3 Remember me, and look on me, punish me not for my sins and ignorances, and the sins of mg fathers, who have sinned before thee: 4 For they obeyed not thy commandments: wherefore thou hast delivered us for a spoil, and unto captivity, and unto death, and for a proverb of reproach to all the nations among whom we are dispersed. 5 And now thy judgments are many and true: deal with me according to my sins and my fathers': because we have not kept thy commandments, neither have walked in truth before thee. 6 Now therefore deal with me as seemeth best unto thee, and command my spirit to be taken from me, that I may be dissolved, and become earth: for it is profitable for me to die rather than to live, because I have heard false reproaches, and have much sorrow: command therefore that I may now be delivered out of this distress, and go into the everlasting place: turn not thy face away from me. 7 It came to pass the same day, that in Ecbatane a city of Media Sara the daughter of Raguel was also reproached by her father's maids; 8 Because that she had been married to seven husbands, whom Asmodeus the evil spirit had killed, before they had lain with her. Dost thou not know, said they, that thou hast strangled thine husbands? thou hast had already seven husbands, neither wast thou named after any of them. 9 Wherefore dost thou beat us for them? if they be dead, go thy ways after them, let us never see of thee either son or daughter. 10 Whe she heard these things, she was very sorrowful, so that she thought to have strangled herself; and she said, I am the only daughter of my father, and if I do this, it shall be a reproach unto him, and I shall bring his old age with sorrow unto the grave. 11 Then she prayed toward the window, and said, Blessed art thou, O Lord my God, and thine holy and glorious name is blessed and honourable for ever: let all thy works praise thee for ever. 12 And now, O Lord, I set I mine eyes and my face toward thee, 13 And say, Take me out of the earth, that I may hear no more the reproach. 14 Thou knowest, Lord, that I am pure from all sin with man, 15 And that I never polluted my name, nor the name of my father, in the land of my captivity: I am the only daughter of my father, neither hath he any child to be his heir, neither any near kinsman, nor any son of his alive, to whom I may keep myself for a wife: my seven husbands are already dead; and why should I live? but if it please not thee that I should die, command some regard to be had of me, and pity taken of me, that I hear no more reproach. 16 So the prayers of them both were heard before the majesty of the great God. 17 And Raphael was sent to heal them both, that is, to scale away the whiteness of Tobit's eyes, and to give Sara the daughter of Raguel for a wife to Tobias the son of Tobit; and to bind Asmodeus the evil spirit; because she belonged to Tobias by right of inheritance. The selfsame time came Tobit home, and entered into his house, and Sara the daughter of Raguel came down from her upper chamber.
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[AD 253] Origen of Alexandria on Tobit 3:1
Regarding the second kind of prayer, see Daniel: “And Azarias standing up prayed in this manner and opening his mouth in the midst of the fire he said …”. And Tobias: “And I began to pray with tears, saying, You are just, O Lord, and all your works are just and all your ways mercy and truth. And your judgments are true and just forever.” And since the passage in Daniel has been obelized on the ground that it is not found in the Hebrew text, and those of the circumcision reject the book of Tobias as not being canonical, I shall quote the words of Anna from the first book of Kings: “And she prayed the Lord, shedding many tears. And she made a vow, saying, O Lord of hosts, if you will look down on the affliction of your servant,” and so on. And in Habakkuk: “A prayer of Habakkuk the prophet with song. O Lord, I have heard your voice and was afraid. O Lord, I reflected on your works and was astonished. In the midst of two animals you will be known; in the approach of the years you will be recognized.” The example just given illustrates very well the definition of prayer inasmuch as he who offers it unites it with praise of God. And again, in the book of Jonah: “Jonah prayed to the Lord his God out of the belly of the fish. And he said, I cried out of my affliction to the Lord my God, and he heard me. Out of the belly of hell you heard the screams of my voice. And you have thrown me into the deep in the heart of the sea, and a flood has surrounded me.”

Source: ON PRAYER 14:4
[AD 735] Bede on Tobit 3:1-17
Sarah, the daughter of Raguel in the city of the Medes, who had been given to seven husbands, and the demon killed them as soon as they went in to her. This symbolically announces the multitude of nations, whose teachers only knew the life of this age, which revolves in seven days, and could say nothing about eternity. Therefore, all of them were seized by the devil, as they were slaves to idolatry, until our true spouse, the Lord, came, who joined her to himself through faith, after overcoming the enemy; just as Tobias took Sarah as his bride after the demon was bound, by the command and cooperation of the archangel, through whom the divinity of our Savior is fittingly signified, just as his humanity is signified by Tobias. Nor should one be surprised that we say that the one person of the Mediator between God and men is symbolized by two persons, namely the angel and the man, who has read in the expositions of the venerable Fathers that his one person suffering for the salvation of the world is prefigured in Isaac, who was offered by his father on the altar, and in the ram, which was sacrificed. He who was killed as a sheep in his humanity, remains impassible in his divinity with God the Father, just as Isaac returned home alive with his father. For if the ram aptly designates the humanity of Christ, the man signifies the divinity; why should not the man much more aptly signify the humanity, and the angel the divinity?

Therefore, the holy angel of the Lord, Raphael, who is interpreted as the medicine of God, was sent to free both Tobias from blindness and Sarah from the demon. The Lord was sent into the world, who said of himself, "It is not the healthy who need a doctor, but the sick" (Luke IV); who also redeemed the Jewish people from the darkness of disbelief, and the gentiles from the bondage of idolatry. Of whom the prophet said: "And his name shall be called the Angel of Great Counsel" (Isa. IX).

Source: Commentary on Tobit
[AD 430] Augustine of Hippo on Tobit 3:12
Accept the sacrifice of my confession as the offering of my tongue, which you have formed and stimulated to confess to your name. Heal all my bones7 and let them say, “Lord, who is like you?” Not that he who confesses to you teaches you anything of what goes on within him, for the heart that is closed does not shut your eye, nor does the hardness of human beings stay your hand. Rather, you soften it, when you desire, either in compassion or in punishment. “There is no one who can hide from your heat.” Rather, my soul praises you, so that it may love you; let it confess to you your mercies, so that it may praise you. Your whole creation never stops or grows silent in your praises—every spirit praises you through the mouth that is turned to you, and all animals and bodily things through the mouth of those who look on them—so that our soul springs up to you from its weakness, supported by those things that you have made and passing over to you who have made these things so wonderfully. There is refreshment and true strength.

Source: Confessions 5.1.1
[AD 253] Origen of Alexandria on Tobit 3:16
It is not only the high priest who prays with those who truly pray, but also the angels, who “have joy in heaven on one sinner who repents, more than on ninety-nine just who need no repentance, and the souls of the saints who have passed away. This is clear from the case of Raphael offering a reasonable sacrifice to God for Tobias and Sarah. For the Scripture says that after they had prayed, “the prayers of them both were heard in the sight of the glory of the great Raphael, and he was sent to heal them both.” And Raphael, in revealing to them his mission to them both, enjoined on him as an angel by God, says, “When you prayed, you and your daughter-in-law Sarah, I offered the memory of your prayer before the Holy One”; and a little further on: “I am Raphael, one of the seven angels who hear the prayers of the saints and enter before the glory of the Holy One.” And so, according to the word of Raphael, “prayer is good with fasting and alms and justice.” And in the case of Jeremiah, who appears in the Maccabees as “admirable for age and glory” so that “an extraordinary dignity and greatness” was about him, and who “stretched forth his right hand and gave to Judas a sword of gold”21—to him another holy man who had died bore witness saying, “This is he who prays much for the people and for all the holy city, Jeremiah the prophet of God.”

Source: ON PRAYER 11:1