22 But now being made free from sin, and become servants to God, ye have your fruit unto holiness, and the end everlasting life.
[AD 420] Jerome on Romans 6:1-23
[Daniel 5:19] "'He slew whomever he would and smote to death whomever he wished to; those whom he wished he set on high, and brought low whomever he would.'" Thus he sets forth the example of the king's great-grandfather, in order to teach him the justice of God and make it clear that his great-grandson too was to suffer similar treatment because of his pride. Now if Nebuchadnezzar slew whomever he would and smote to death whomever he wished to; if he set on high those whom he would and brought low whomever he wished to, there is certainly no Divine providence or Scriptural injunction behind these honors and slayings, these acts of promotion and humiliation. But rather, such things ensue from the will of the men themselves who do the slaying and promoting to honor, and all the rest. If this be the case, the question arises as to how we are to understand the Scripture: "The heart of a king reposes in the hand of God; He will incline it in whatever direction He wishes" (Proverbs 21:1). Perhaps we might say that every saint is a king, for sin does not reign in his mortal body, and his heart therefore is kept safe, for he is in God's hand (Romans 6:1-23). And whatever has once come into the hand of God the Father, according to the Gospel, no man is able to take it away (John 10:28). And whoever is taken away, it is understood that he never was in God's hand at all.

[AD 215] Clement of Alexandria on Romans 6:22
And the apostle, succinctly describing the end, writes in the Epistle to the Romans: "But now, being made free from sin, and become servants to God, ye have your fruit unto holiness, and the end everlasting life."

[AD 220] Tertullian on Romans 6:22
Throughout this chapter, while withdrawing our members from unrighteousness and sin and applying them to righteousness and holiness, and transferring the same from the wages of death to the gift of eternal life, Paul undoubtedly promises to the flesh the reward of salvation. Now it would not have been consistent for a rule of holiness and righteousness to be especially enjoined for the flesh if the reward of such a discipline were not also within its reach; nor could even baptism be ordered for the flesh if by its regeneration a course were not inaugurated tending to its restitution.

[AD 253] Origen of Alexandria on Romans 6:22
Paul repeats what he has already said [in verse 18] but with an important difference. There he said that we have become slaves to obedience, which leads to righteousness, but here he says that we have become slaves to God. By saying this, Paul shows that after someone has been set free from sin he ought to serve righteousness and perform all the virtues in the first instance and then ascend by the way of spiritual progress to the point where he becomes a slave of God, even though to be a slave of righteousness is also to be a slave of God. For Christ is righteousness, and to serve Christ is to serve God. Nevertheless, there is a scale of spiritual perfection, and there are different levels of virtue. For this reason Christ is said to reign, because he is righteousness, until such time as the fullness of all virtue is complete in everyone. Then, when the measure of perfection is reached, it is said that he will give up the kingdom to God the Father, so that God may be all in all.

[AD 384] Ambrosiaster on Romans 6:22
If when we receive the forgiveness of sins we become imitators of good deeds, we shall acquire holiness and we shall obtain eternal life at the end, for we shall pass from death, which Paul said was the end, to life, which is without end.

[AD 407] John Chrysostom on Romans 6:22
Of the former, the fruit was shame, even after the being set free. Of these the fruit is holiness, and where holiness is, there is all confidence. But of those things the end is death, and of these everlasting life. Do you see how he points out some things as already given, and some as existing in hope, and from what are given he draws proof of the others also, that is from the holiness of the life. For to prevent your saying (i.e. as an objection) everything lies in hope, he points out that you have already reaped fruits, first the being freed from wickedness, and such evils as the very recollection of puts one to shame; second, the being made a servant unto righteousness; a third, the enjoying of holiness; a fourth, the obtaining of life, and life too not for a season, but everlasting. Yet with all these, he says, do but serve as you served it. For though the master is far preferable, and the service also has many advantages, and the rewards too for which you are serving, still I make no further demand. Next, since he had mentioned arms and a king, he keeps on with the metaphor in these words: (Romans 6:23)

[AD 407] John Chrysostom on Romans 6:22
Instead of the shame and death which you deserved before, you now have the hope of attaining holiness and eternal life. Note how Paul says that some things have already been given, while others are still hoped for, but that the former point to the latter. Thus if we can come to holiness now, we can be assured of obtaining eternal life in the future.

[AD 418] Pelagius on Romans 6:22
Doubtless there is no blessing in something for which one feels shame when repenting of it. Everyone who comes to know goodness is ashamed of his former actions, but anyone who is ashamed of righteousness is not aware of its fruit. Therefore, those who sin get nothing out of it in the present, and in the future they will reap eternal death. But those who serve God have the gift of the Holy Spirit in the present and eternal life in the future. Or perhaps it should be read like this: what have you got out of doing things which make you feel ashamed whenever you think of them? The return you have already received is that, having been sanctified by baptism, you are alive.