12 Let not sin therefore reign in your mortal body, that ye should obey it in the lusts thereof.
[AD 420] Jerome on Romans 6:1-23
[Daniel 5:19] "'He slew whomever he would and smote to death whomever he wished to; those whom he wished he set on high, and brought low whomever he would.'" Thus he sets forth the example of the king's great-grandfather, in order to teach him the justice of God and make it clear that his great-grandson too was to suffer similar treatment because of his pride. Now if Nebuchadnezzar slew whomever he would and smote to death whomever he wished to; if he set on high those whom he would and brought low whomever he wished to, there is certainly no Divine providence or Scriptural injunction behind these honors and slayings, these acts of promotion and humiliation. But rather, such things ensue from the will of the men themselves who do the slaying and promoting to honor, and all the rest. If this be the case, the question arises as to how we are to understand the Scripture: "The heart of a king reposes in the hand of God; He will incline it in whatever direction He wishes" (Proverbs 21:1). Perhaps we might say that every saint is a king, for sin does not reign in his mortal body, and his heart therefore is kept safe, for he is in God's hand (Romans 6:1-23). And whatever has once come into the hand of God the Father, according to the Gospel, no man is able to take it away (John 10:28). And whoever is taken away, it is understood that he never was in God's hand at all.

[AD 202] Irenaeus on Romans 6:12
And for this reason he says, in the Epistle to the Romans: "Let not sin, therefore, reign in your mortal body, to be under its control: neither yield ye your members instruments of unrighteousness unto sin; but yield yourselves to God, as being alive from the dead, and your members as instruments of righteousness unto God."

[AD 202] Irenaeus on Romans 6:12
In these same members in which we used to serve sin and bring forth fruit unto death, God wants us to be obedient unto righteousness, that we may bring forth fruit unto life.

[AD 223] Callistus I of Rome on Romans 6:12
Being then made free from sin, ye became the servants of righteousness. I speak after the manner of men."
[AD 253] Origen of Alexandria on Romans 6:12
The apostle declares that all sins are works of the flesh.… Now if it were not in our power that sin should not reign in us, he would not have given us this command. How then is it possible that sin should not reign in our flesh? It is possible if we do what the apostle says—“Put to death what is earthly in you”—and if we always carry around in our body the death of Christ. For it is certain that where the death of Christ is carried around sin cannot reign. For the power of the cross of Christ is such that if it is placed before our eyes and kept faithfully in mind in such a way that the eye of the mind may keep its gaze fixed on the death of Christ, no lust, no desire, no passion and no envy will be able to overcome it. At its presence the whole host of sin and the flesh will always flee.Why does Paul add that the body is “mortal,” when this seems to be obvious? Perhaps, but I think there is a reason for this addition. For Paul was showing by this how it is possible for sin not to reign in our bodies.… If we realize that our body can be put to death and be dead to sin, it may happen that sin will not reign in it. Insofar as it is dead, it is said to be justified from sin. Nor does a dead man lust or get angry or have passions or steal what is not his. Therefore, if we suppress all these desires in our bodies they may be said to be dead to sin. This is what the apostle appears to be telling us by adding the adjective mortal in this context. COMMENTARY ON THE EPISTLE TO THE ROMANS.
DIODORE:What sin is this? The sin committed before baptism, of course.

[AD 384] Ambrosiaster on Romans 6:12
The body is mortal because of the sin of Adam, but by faith in Christ we believe that it will be immortal. But in order for it to inherit the promise, Paul says that it must not listen to the voice of sin, so that sin may not reign in our mortal body. For it reigns as long as it is in control. But if it does not reign, the body will no longer appear to be mortal, because it dwells in the hope of eternal life. Paul did not say that the body is mortal because it will disintegrate but because of the pain of hell, so that the man who is sent to hell is said to be mortal because whoever hearkens to sin will not escape the second death, from which the Savior has delivered those who believe in him. Therefore, the mortal body refers to the entire human being because those who hearken to sin are said to be mortal. For Scripture says: “The soul which sins shall surely die,” which means the whole human being. For nobody will be judged apart from his body.

[AD 390] Diodorus of Tarsus on Romans 6:12
What sin is this? The sin committed before baptism, of course. .
[AD 407] John Chrysostom on Romans 6:12
He does not say, let not the flesh live or act, but, "let not sin reign," for He came not to destroy our nature, but to set our free choice aright. Then to show that it is not through any force or necessity that we are held down by iniquity, but willingly, he does not say, let it not tyrannize, a word that would imply a necessity, but let it not reign. For it is absurd for those who are being conducted to the kingdom of heaven to have sin empress over them, and for those who are called to reign with Christ to choose to be the captives of sin, as though one should hurl the diadem from off his head, and choose to be the slave of a frantic woman, who came begging, and was clothed in rags. Next since it was a heavy task to get the upper hand of sin, see how he shows it to be even easy, and how he allays the labor by saying, "in your mortal body." For this shows that the struggles were but for a time, and would soon bring themselves to a close. At the same time he reminds us of our former evil plight, and of the root of death, as it was from this that, contrary even to its beginning, it became mortal. Yet it is possible even for one with a mortal body not to sin. Do you see the abundancy of Christ's grace? For Adam, though as yet he had not a mortal body, fell. But you, who hast received one even subject to death, can be crowned. How then, is it that "sin reigns?" he says. It is not from any power of its own, but from your listlessness. Wherefore after saying, "let it not reign," he also points out the mode of this reigning, by going on to say "that you should obey it in the lusts thereof." For it is not honor to concede to it (i.e. to the body) all things at will, nay, it is slavery in the extreme, and the height of dishonor; for when it does what it lists, then is it bereft of all liberties; but when it is put under restraints, then it best keeps its own proper rank.

[AD 407] John Chrysostom on Romans 6:12
It is absurd for those who are being led toward the kingdom of God to have sin ruling over them or for those who are called to reign with Christ to choose to be captives to sin, as if one should throw down the crown from off his head and choose to be the slave of a hysterical woman who comes begging and covered in rags.… How is it that sin can reign in you? It is not from any power of its own but only from your laziness. HOMILIES ON ROMANS 11.JEROME:Because men are not my masters, because sin is not my lord—for sin does not reign in my mortal body—I am your servant.

[AD 418] Pelagius on Romans 6:12
You should live in your mortal body as if you were immortal. Paul also explains how sin reigns in the body—by obedience and consent.

[AD 420] Jerome on Romans 6:12
Because men are not my masters, because sin is not my lord—for sin does not reign in my mortal body—I am your servant.
[AD 430] Augustine of Hippo on Romans 6:12
The reign of sin is overthrown and destroyed, partly by such an amendment on the part of men that the flesh is made subject to the spirit and partly by the condemnation of those who are persevering in sin, in order that they might be so justly restrained that they cannot be troublesome to the righteous, who reign with Christ.

[AD 430] Augustine of Hippo on Romans 6:12
We must engage in a constant, daily struggle not to obey those desires which are forbidden or improper. For from this sort of fault it comes about that the eye is turned to where it ought not to look, and if this fault grows strong and prevails, even bodily adultery is carried out, which is committed in the heart as much more quickly as thought is quicker than action and has nothing to hinder or delay it.

[AD 458] Theodoret of Cyrus on Romans 6:12
A reign is different from a tyranny in that a tyrant rules without the consent of his subjects, whereas a reign applies in those cases where the subjects have assented to it. Therefore Paul is urging his hearers not to assent any longer to the reign of sin, for the Lord destroyed sin’s reign when he took on human flesh.

[AD 471] Gennadius of Constantinople on Romans 6:12
Here Paul shows that the reason we no longer sin is not that after baptism we are no longer made of flesh. Up to this point, we claim Christ’s perfection by faith only and not by experience. For we have not yet become impassible or immortal.… Therefore Paul does not say: “Do not sin,” but rather: “Let not sin reign in your mortal bodies.”

[AD 542] Caesarius of Arles on Romans 6:12
Paul did not say: “Let sin not exist,” but “Let it not reign.” Sin is within you if you take delight in it; it reigns if you consent to it.

[AD 1274] Thomas Aquinas on Romans 6:12
After showing that we ought not remain in sin [n. 470] and that we have the faculty for this [n. 478], the Apostle concludes with a moral exhortation. And concerning this he does three things: 249 first, he proposes an admonition; secondly, he assigns a reason [v. 14; n. 496]; thirdly, he raises and solves a question [v. 15; n. 499]. In regard to the first he does two things: first, he proposes the admonition; secondly, he clarifies [v. 12b; n. 494]. 493. First, therefore, he says: We have said that our old self was crucified once, so that the body of sin may be destroyed. This means that the power of sin has been so weakened that it cannot rule us. Therefore, let not sin reign in your mortal bodies any longer. He does not say: Let not sin be in your mortal body, because as long as our body is mortal, it is not possible for sin not to be in our body, i.e., the inclination to sin. But since we have been freed from the kingdom of sin by God, we must struggle in order that sin not recover its dominion now lost in our body. And this is what he says: Let not sin reign in your mortal body. This is something about which one must be on his guard, as long as we wear the mortal body: "The corruptible body is a load upon the soul" (Wis 9:15). 494. Then (v.12b) he clarifies this admonition. In regard to this it should be noted that sin reigns in man in two ways: in one way, through internal consent of the mind. To remove this he says: to make you obey their passions. For it is by obeying the passions of sin with our minds that sin reigns in us: "Go not after thy lusts" (Si 18:30). 250 In a second way sin reigns in us by performing the act. To exclude this, he adds: do not yield your members to sin, i.e., to the inclination to sin, as instruments of wickedness. For when man commits sin through his members, he yields to sin. In this way he seeks to restore sin’s dominion, which grows in us through the habit of sinning: "They went down to hell with their weapons" (Ex 32:27). 495. Then (v.13b) he urges them to the opposite, namely, to mold themselves to God. And first with regard to the internal faculties when he says: But yield yourselves to God by submitting your mind to God: "And now, Israel, what does the Lord thy God require of you but that you fear the Lord your God and walk in his ways" (Dt 10:12). And you ought to do this as men who have been brought from death to life, i.e., as led from the death of sin to the life of grace. Hence it is fitting, since he died for all, "that those who live might no longer live for themselves but for him who for their sake died and was raised" (2 Cor 3:15). Secondly, with respect to outward actions; hence he says: Yield your members to God, i.e., to his service, as instruments of righteousness with which to fight against God’s enemies: "Put on the whole armor of God, that you may be able to stand against the wiles of the devil" (Eph 6:11). 496. Then (v.14) he assigns the reason for this admonition. For someone might excuse himself, alleging that sin’s dominion is an obstacle to obeying the admonition. But the Apostle excludes this, saying: For sin will have no dominion over you, i.e., if you begin to resist sin and yield yourself to God: "Draw near to God and he will draw near to you. Resist the devil and he will flee from you" (Jas 251 4:8). As if to say: You can observe my admonition, because you do not find sin dominating and holding you. For we have been freed by Christ, as Jn (8:36) says: "If the Son makes you free, you will be free indeed." 497. Then he clarifies what he had said, saying: For you are not under the law but under grace. Here it should be noted that he is not speaking of the Law merely with respect to its ceremonial precepts, but even with respect to moral matters. For one is said to be under the Law in two ways: in one way, as voluntarily subject to the observance of the Law. Even Christ was under the Law in this way according to Gal (4:4): "Born under the law," namely, because he observed the Law, not only the moral but also the ceremonial precepts. But the faithful of Christ are under the Law in this way, with respect to the moral precepts but not the ceremonial. In another way, one is said to be under the Law as though compelled by the Law. In this way, one is under the Law when he does not obey it voluntarily from love but is compelled by fear. But such a one lacks grace which, if it were present, would incline the will to observe the Law and fulfill its moral precepts from a motive of love. Therefore, as long as one is under the Law in such a way that he does not fulfill it voluntarily, sin has dominion over him. As a result, such a man’s will is inclined to choose what is contrary to the law. But through grace such dominion is removed; consequently, a man observes the Law not as existing under the Law but as free: "We are not children of the slave but of the free woman, by the freedom with which Christ has sat us free" (Gal 4:31). 252 498. This grace, making men freely obey the Law, was not conferred by the sacraments of the Old Law, but Christ’s sacraments conferred it. Consequently, those who submitted themselves to the ceremonies of the Law were not, so far as the power of those sacraments was concerned, under grace but under the Law, unless they happened to obtain grace through faith. But one who submits to Christ’s sacraments obtains grace from his power, so as not to be under the Law but under grace, unless they enslaved themselves to sin through their own fault. 499. Then (v. 15) he raises a question against what he has said. And concerning this he does three things: first, he raises the question; secondly, he answers it [v. 16; n. 501]; thirdly, he shows how awkward it would be to misinterpret his statement [v. 17; n. 502]. 500. In regard to the first it should be noted that his statement could be falsely interpreted, namely, that Christ’s faithful are not under the Law with respect to being obliged to obey its moral precepts. For it would follow that Christ’s faithful could lawfully commit sin and act against the moral precepts. Therefore, in this context he raises the question: What then? Are we to sin, i.e., act against the moral precepts, because, as has been said, we are not under the law but under grace? This interpretation the Apostle rejects in Gal (5:13): "For you were called to freedom, brethren, only do not use your freedom as an opportunity for the flesh." 253 23 Ambrose, De Paradiso, ch. 8. 501. In the same fashion he answers here: By no means should we sin because we have been set free from the Law; because if we were to sin, we would once more be reduced to the slavery of sin. Hence, he continues: Do you not know that if you yield yourselves of your own will to anyone as obedient slaves, you are voluntarily the slaves of the one whom you obey. For obedience is a debt which slaves owe to their master: "Slaves, be obedient to your earthly masters" (Eph 6:5). Hence, when someone obeys another, he admits that he is his slave by obeying. But different masters are obeyed for different remunerations. For the one who obeys sin is led to death through the slavery of sin. And this is what he says: either of sin, i.e., you are its slaves by obeying it, which leads to death, i.e., to the eternal damnation of the one who falls. Concerning this death it says in Rev (2:11): "He who conquers shall not be hurt by the second death." But the one who obeys God is made a slave of this obedience, because through the habit of obeying the mind is inclined more and more to obeying and as a result achieves holiness. Therefore, he says: or of obedience, namely, of the divine precepts, which leads to righteousness: "It is the doers of the law who will be justified" (Rom 2:13). Sin and obedience are fittingly presented as opposites, because, as Ambrose says, sin is a transgression of the divine law, disobedience against the heavenly commands.23 502. Then (v.17) he shows the folly o obeying sin and thereby returning to the slavery of sin: first, by considering the benefit we have received. For if someone, by another’s graciousness is freed from slavery, it is foolish to subject oneself freely to slavery. Hence, since we have been freed from sin by the grace of God, it is foolish willfully to return to the slavery of sin. 254 Secondly, by considering the state into which we were placed after freedom from sin, namely, that we are slaves to righteousness. But, it is not lawful for a slave to subject himself to the dominion of an opposite master; hence, it is not lawful, if we have been made slaves of righteousness, to return to the slavery of sin. 503. The Apostle touches on both of these considerations, when he says: I thank God, and you too should thank God, that you who were once slaves of sin may become obedient, namely, by believing, not as though compelled but from the heart: "For man believes with the heart and so is justified" (Rom 10:10) to the standard of teaching, i.e., to the doctrine of the Catholic faith: "Follow the pattern of the sound words you have heard from me" (2 Tim 1:13) to which you were committed: i.e., gave yourselves entirely: "But first they gave themselves to the Lord and to us by the will of God" (2 Cor 8:5). And having been set free from sin, so that it is not fitting for you to return to the slavery of sin, you have become slaves of righteousness, so that it is not fitting to desert righteousness: "You were bought with a price" (1 Cor 7:23) and are not your own.