21 Acquaint now thyself with him, and be at peace: thereby good shall come unto thee.
[AD 253] Origen of Alexandria on Job 22:21-25
This is what he means, in my opinion: “Confess your sins; receive from God’s mouth his support after your confession; and take his words into your heart.” Certainly Eliphaz said these things, as he believed, by making himself equal to Job.… However, he pronounces a correct dogma here. He, in fact, thinks that Job suffers his adversities because of his sins but also so that he will be purified through the endurance of his afflictions. Once he is purified, he will be delivered from any extraneous element and freed from any involvement with iniquity. And like gold refined in a melting pot, he will appear to be tested. If you, he says, endure what has happened to you, God will make you pure, like silver purified with fire.

[AD 373] Ephrem the Syrian on Job 22:21-25
This means that you will be restored to your former state. And God will be your helper while before it seemed that he had completely neglected the care of your salvation, as if he had been absent.

[AD 604] Gregory the Dialogist on Job 22:21
20. There is the sin of pride in teaching one better than one’s self, which heretics are often guilty of, who touching things which they have wrong notions of, take upon them as if to instruct Catholics. For such they think are then ‘at one with God,’ if it chance for them to assent to their bad ways; and to those thus ‘at one’ they promise peace in that they henceforth cease to quarrel with those who agree with themselves. Now ‘the best fruits’ they promise to those agreeing with themselves, in that they believe that they only do good works, whom they triumph in themselves drawing in to their own tenets; which persons this also suits that he adds, Receive, I pray, the law out of His mouth; because the things they think of their own heads, they fancy proceed from the mouth of God. And lay up His words in thine heart; as if he asserted it in plain words, saying, ‘which up to this present time in thy mouth thou hast held, and not in thine heart.’ For because he [al. Holy Church] rejected their corrupted tenets, they allege against him [al. her, &c.] that the words of God he had held not in the feeling, but in the showing off. Whence, as if under a certain appearance of sweetness, they insinuate the poison of pestilent persuading, so as to admonish the Church to lay up the words of God in the heart; which words, if they had ever departed from her heart, from those persons she would never have heard such things.