Let us admit, he says, that I am iniquitous and impious; but I gain no profit from these remarks and know that you will mock me; therefore, I do not yield. “And what!” he says, “is it a mortal who blames me?” that is, no mortal can blame me. I am not fighting against a man. “When I think of it, I am dismayed and pains seize my flesh.” Notice how he always stands up, how he puts forward his sufferings, how he indicates the reason for the terrible words he is going to speak, because he does not talk in this manner by himself or from a fixed position but because his soul is dismayed and his thoughts are darkened.
42. Whosoever in pleasing God displeases man, has no grounds for sadness. But he, who in pleasing man displeases God, or thinks that he displeases both God and man together, if sadness does not come upon him, proves a stranger to the excellency of wisdom. Now blessed Job believed that he had displeased God in the midst of his strokes, and therefore he called back his mind to sadness, in that He was not to be disregarded, Whom he was afraid that he had displeased. Now, if he had been pleading against man concerning the merits of his life, he would have had no occasion to feel sadness, but seeing that by his present strokes he was made doubtful of his past life, he justly sought for sadness under the scourge.
[AD 407] John Chrysostom on Job 21:4-6