(v. 15) So why did he become prey? The lions roared against him and gave forth their voice. They made his land a desolation; his cities are burned and no one lives in them. The divine speech asks a question in order to answer it. But indeed, the lions can be understood as the princes of Babylon, who made their land a desolation and destroyed their cities with fire. Or certainly, by way of anagoge, we can understand the lions as adversarial powers or the leaders of heretics, who devastate the land of the Church and lay waste to all her cities with heretical fire, the fire about which it is written: "All of them are adulterers, their hearts are like an oven" (Hosea 7:4). For they truly give their voice, and in this same prophet under the figure of the partridge they cry out: They gather what they have not brought forth: they make riches, but not with judgment (Jerem. XVII, 17). Therefore, her cities have been devastated and destroyed: because they do not have God as an inhabitant, as the Scripture says: And there is no one who dwells in them (Ibid., 4).
[AD 420] Jerome on Jeremiah 2:15