(Verse 6, 7.) Go to Carthage: howl, you who dwell in this island. Is this not your insult from the beginning before it was handed over? They will lead it far on foot to wander. That which follows: They will lead it far on foot to wander, is added from Hebrew, and is prenoted by an asterisk, that is, by illuminating stars. O Tyrians who dwell in narrowness and reside on the island, who are exposed on all sides to the waves of trials, depart from it, and go to Carthage, that is, to Tharsis, and hasten to true joy, mourning for ancient sins, and for the old insult, which either you yourselves inflicted on others, or suffered from them. But I give this command for a reason: because you see your city Tyre about to be moved from its original seats and purpose, when they have humbled their necks to the Gospel of the Savior, after having cast away their old error. So that those who previously dwelled in narrowness may withdraw farther and become strangers and inhabitants of the teaching of the Lord, the Savior.
(Verse 6.) Cross over, O sea! Cry out, you who dwell on the island! Once again, they have carried Carthage across the sea and to Tharsis, seventy ships. We read in the histories of the Assyrians that the besieged Tyrians, seeing no hope of escape, fled to Carthage, either to other islands of the Ionian and Aegean seas. Hence it is said in Ezekiel: No wages were given to him, nor to his army from Tyre (Ezek. 29); because all the wealth of the city has been transferred, and all its nobles have abandoned it empty.
[AD 420] Jerome on Isaiah 23:6-7