15 We who are Jews by nature, and not sinners of the Gentiles,
[AD 407] John Chrysostom on Galatians 2:15
Ver. 15. "We being Jews by nature, and not sinners of the Gentiles."

These words are hortatory, but are couched in the form of a reproof, on account of those Jews. So elsewhere, under cover of one meaning he conveys another; as where he says in his Epistle to the Romans, "But now I go unto Jerusalem, ministering unto the saints." [Romans 15:25] Here his object was not simply to inform them of the motive of his journey to Jerusalem, but to excite them to emulation in the giving of alms. Had he merely wished to explain his motive, it would have sufficed to say, "I go to ministering unto the saints;" but now observe what he says in addition; "For it has been the good pleasure of Macedonia and Achaia to make a certain contribution for the poor among the saints that are at Jerusalem. Yea, it has been their good pleasure and their debtors they are." And again, "For if the Gentiles have been made partakers of their spiritual things, they owe it to them, also to minister unto them in carnal things." [Romans 15:26-27]

Observe how he represses the high thoughts of the Jews; preparing for one thing by means of another, and his language is authoritative. "We being Jews by nature, and not sinners of the Gentiles." The phrase, "Jews by nature," implies that we, who are not proselytes, but educated from early youth in the Law, have relinquished our habitual mode of life, and be taken ourselves to the faith which is in Christ.

[AD 420] Jerome on Galatians 2:15
A Jew by nature is one of Abraham’s stock, who has been circumcised by his parents on the eighth day. One who is a Jew “not by nature” is one of Gentile origin who has been subsequently made so. That I may embrace the whole argument in a brief discourse, the sense of the text is as follows: “We are Jews by nature, doing those things that were precepts of the law. We are not sinners who come from the Gentiles—either in the sense of those who are sinners generically because they worship idols or those whom Jews now regard as unclean. Yet we know that we cannot be saved by the works of the law but rather by faith in Christ. We have believed in Christ that what the law had not given us our faith would guarantee to us. Seceding from the law in which we could not be saved, we have gone over to faith, in which not the circumcision of the flesh but the devotion of a pure heart is demanded. But what if we now belatedly declare by seceding from the Gentiles that whoever is uncircumcised is unclean? In that case faith in Christ—by which we previously thought we were saved—would rather become a minister of sin than of righteousness. For faith would under that assumption take away the circumcision without which one is unclean.”

[AD 420] Jerome on Galatians 2:15
(Verse 15) We are by nature Jews, and not sinners from the Gentiles. At this point, heretics sneak in, who, inventing ridiculous and foolish things, say that the spiritual nature cannot sin, nor can the earthly nature do anything just. Let us ask them why branches of the good olive tree were broken off and why branches from a wild olive tree were grafted onto the root of the good olive tree, if nothing can fall from good or rise from evil. Or how was Paul persecuting the Church before he became an Apostle if he was of a spiritual nature? Or how did he become an Apostle afterwards if he was generated from earthly sediment? But if they contend that He was not of earthly origin, let us set down His own words: 'We were by nature children of wrath, like the others' (Ephesians II, 3). The Jew by nature is one who is of the race of Abraham and was circumcised by his parents on the eighth day. Not the Jew by nature, who later became one from the Gentiles. But to sum up the whole argument in a few words, this is the sense that is being expressed: 'We', that is, 'I and you, Peter' (for He mixed in His own person, lest it might seem that He was doing injury to them), when we were, He says, Jews by nature, doing the things that were commanded by the Law, and not sinners from among the Gentiles, who either generally, because they serve idols, are sinners, or those whom we now consider unclean, knowing that we cannot be saved by the work of the Law, but by faith in Christ, we believed in Christ, so that what the Law did not give us, faith bestowed on us in Christ.' But if, departing from the Law in which we could not be saved, we turn to faith, in which circumcision of the flesh is not sought but rather devotion of a pure heart, and now by turning away from the Gentiles we do this, so that whoever is not circumcised may be unclean; therefore, faith in Christ, in which we thought we were saved before, is more a minister of sin than of justice, which removes circumcision, and whoever does not have it is unclean. But far be it from me to seek revenge, now that I know that what I once destroyed and considered as useless to me. Once I departed from the Law, I died to the Law in order to live in Christ, and I was crucified with Him, and I was reborn as a new man, relying more on faith than on flesh, and with Christ I departed from the world. What I once embraced, I hold fast. Christ did not die for me in vain: in Him I believed in vain, if I could be saved without faith in Him in the old Law.

[AD 430] Augustine of Hippo on Galatians 2:15
The Jews had given the name of sinners to the Gentiles through a certain pride, already inveterate. It is as though they themselves were just, seeing the mote in another’s eye and not the beam in their own.

[AD 749] John Damascene on Galatians 2:15
Having worked out from the case of those around Peter that circumcision should not be applied, he now works this out in a more complete way. For if those who were Jews from childhood, and not prostylites, but having been brought up in the Law, having seen the weakness of the Law in justifying man, transpose themselves to the grace through faith, how much more those who were not from the beginning from the Law, but from the nations, and having later come to believe in Christ, are not obliged to incline themselves to the Law which is impotent in making one upright.