2 Set your affection on things above, not on things on the earth.
[AD 160] Shepherd of Hermas on Colossians 3:2
But such as entertain wicked thoughts in their minds are bringing upon themselves death and captivity; and especially is this the case with those who set their affections on this world, and glory in their riches, and look not forward to the blessings of the life to come.

[AD 230] Pope Urban I on Colossians 3:2
) rather things above, and not things on the earth;
[AD 325] Lucius Caecilius Firmianus Lactantius on Colossians 3:2
This is the reason why no one obeys their precepts; inasmuch as they either train men to vices, if they defend pleasure; or if they uphold virtue, they neither threaten sin with any punishment, except that of disgrace only, nor do they promise any reward to virtue, except that of honour and praise only, since they say that virtue is to be sought for its own sake, and not on account of any other object. The wise man therefore is happy under tortures; but when he suffers torture on account of his faith, on account of justice, or on account of God, that endurance of pain will render him most happy. For it is God alone who can honour virtue, the reward of which is immortality alone. And they who do not seek this, nor possess religion, with which eternal life is connected, assuredly do not know the power of virtue, the reward of which they are ignorant; nor look towards heaven, as they themselves imagine that they do, when they inquire into subjects which do not admit of investigation, since there is no other cause for looking towards heaven, unless it be either to undertake religion, or to believe that one's soul is immortal. For if any one understands that God is to be worshipped, or has the hope of immortality set before him, his mind is in heaven; and although he may not behold it with his eyes, yet he does behold it with the eye of his soul.

[AD 395] Gregory of Nyssa on Colossians 3:2
So … if reason instead assumes sway over such emotions, each of them is transmuted to a form of virtue. For anger produces courage, terror caution, fear obedience, hatred aversion from vice, the power of love the desire for what is truly beautiful. High spirit in our character raises our thought above the passions and keeps it from bondage to what is base. Indeed, even the great apostle praises such a form of mental elevation when he bids us constantly to “think those things that are above.” So we find that every such motion, when elevated by loftiness of mind, is conformed to the beauty of the divine image.
[AD 407] John Chrysostom on Colossians 3:2-4
"Set your mind on the things that are above, not on the things that are upon the earth. For ye died, and your life is hid with Christ in God. When Christ who is your life shall be manifested, then shall ye also with Him be manifested in glory."

This is not your life, he saith, it is some other one. He is now urgent to remove them, and insists upon showing that they are seated above, and are dead; from both considerations establishing the position, that they are not to seek the things which are here. For whether ye be dead, ye ought not to seek them; or whether ye be above, ye ought not to seek them. Doth Christ appear? Neither doth your life. It is in God, above. What then? When shall we live? When Christ shall be manifested, who is your life; then seek ye glory, then life, then enjoyment.

This is to prepare the way for drawing them off from pleasure and ease. Such is his wont: when establishing one position, he darts off to another; as, for instance, when discoursing of those who at supper were beforehand with one another, he all at once falls upon the observance of the Mysteries. For he hath a great rebuke when it is administered unsuspected. "It is hid," he saith, from you. "Then shall ye also with Him be manifested." So that, now, ye do not appear. See how he hath removed them into the very heaven. For, as I said, he is always bent upon showing that they have the very same things which Christ hath; and through all his Epistles, the tenor is this, to show that in all things they are partakers with Him. Therefore he uses the terms, Head, and Body, and does everything to convey this to them.

If therefore we shall then be manifested, let us not grieve, when we enjoy not honor: if this life be not life, but it be hidden, we ought to live this life as though dead. "Then shall ye also," he saith, "with Him be manifested in glory." "In glory," he said, not merely "manifested." For the pearl too is hidden so long as it is within the oyster. If then we be treated with insult, let us not grieve; or whatever it be we suffer; for this life is not our life, we are strangers and sojourners. "For ye died," he saith. Who is so witless, as for a corpse, dead and buried, either to buy servants, or build houses, or prepare costly raiment? None. Neither then do ye; but as we seek one thing only, namely, that we be not in a naked state, so here too let us seek one thing and no more. Our first man is buried: buried not in earth, but in water; not death-destroyed, but buried by death's destroyer, not by the law of nature, but by the governing command that is stronger than nature. For what has been done by nature, may perchance be undone; but what has been done by His command, never. Nothing is more blessed than this burial, whereat all are rejoicing, both Angels, and men, and the Lord of Angels. At this burial, no need is there of vestments, nor of coffin, nor of anything else of that kind. Wouldest thou see the symbol of this? I will show thee a pool wherein the one was buried, the other raised; in the Red Sea the Egyptians were sunk beneath it, but the Israelites went up from out of it; in the same act he buries the one, generates the other.

Marvel not that generation and destruction take place in Baptism; for, tell me, dissolving and cementing, are they not opposite? It is evident to all. Such is the effect of fire; for fire dissolves and destroys wax, but it cements together metallic earth, and works it into gold. So in truth here also, the force of the fire, having obliterated the statue of wax, has displayed a golden one in its stead; for in truth before the Bath we were of clay, but after it of gold. Whence is this evident? Hear him saying, "The first man is of the earth, earthy, the second man is the Lord from heaven." I spoke of a difference as great as that between clay and gold; but greater still do I find the difference between heavenly and earthy; not so widely do clay and gold differ, as do things earthy and heavenly. Waxen we were, and clay-formed. For the flame of lust did much more melt us, than fire doth wax, and any chance temptation did far rather shatter us than a stone doth things of clay.