8 We are troubled on every side, yet not distressed; we are perplexed, but not in despair;
[AD 215] Clement of Alexandria on 2 Corinthians 4:8
Only let us preserve free-will and love: "troubled on every side, yet not distressed; perplexed, but not in despair; persecuted, but not forsaken; cast down, but not destroyed."

[AD 220] Tertullian on 2 Corinthians 4:8
Rather, dishonour and weakness will accrue to him, because the earthen vessels with which he had nothing to do have received all the excellency! Well, then, if it be in these very earthen vessels that he tells us we have to endure so great sufferings, in which we bear about with us the very dying of God, (Marcion's) god is really ungrateful and unjust, if he does not mean to restore this same I substance of ours at the resurrection, wherein so much has been endured in loyalty to him, in which Christ's very death is borne about, wherein too the excellency of his power is treasured.

[AD 220] Tertullian on 2 Corinthians 4:8
He also says, in verses occurring in a previous part of the epistle: "Our condition is such, that we are troubled on every side, yet not distressed; and are in need, but not in utter want; since we are harassed by persecutions, but not forsaken; it is such that we are east down, but not destroyed; always bearing about in our body the dying of Christ." "But though," says he, "our outward man perisheth"-the flesh doubtless, by the violence of persecutions-"yet the inward man is renewed day by day"-the soul, doubtless, by hope in the promises.

[AD 253] Origen of Alexandria on 2 Corinthians 4:8
For God delivers us from afflictions not when we are no longer in affliction (… Paul says “we are afflicted in every way,” as though there were never a time when we were not afflicted), but when in our affliction we are not crushed because of God’s help. “To be afflicted,” according to a colloquial usage of the Hebrews, has the meaning of a critical circumstance that happens to us without our free choice, while “to be crushed” implies our free choice and that it has been conquered by affliction and given into its power. And so Paul is right when he says, “We are afflicted in every way but not crushed.”

[AD 253] Origen of Alexandria on 2 Corinthians 4:8
And unless we understand something that has escaped the notice of the many concerning praying not to enter into temptation, it is time to say that the apostles sometimes prayed and were not heard. How many thousand sufferings did they experience throughout their lifetimes with far greater labors, with far more beatings, with countless imprisonments, and often near death? Paul on his own received at the hands of the Jews the forty lashes less one, was beaten with rods three times, was stoned once, was shipwrecked three times, was adrift at sea a night and a day. He was in every way afflicted, perplexed, persecuted and struck down.

[AD 407] John Chrysostom on 2 Corinthians 4:8-9
We are pressed on every side, yet not straitened; perplexed, yet not unto despair; pursued, yet not forsaken.

He still dwells upon proving that the whole work is to be ascribed to the power of God, repressing the highmindedness of those that glory in themselves. 'For not this only,' says he, 'is marvelous, that we keep this treasure in earthen vessels, but that even when enduring ten thousand hardships, and battered on every side, we [still] preserve and lose it not. Yet though there were a vessel of adamant, it would neither have been strong enough to carry so vast a treasure, nor have sufficed against so many machinations; yet, as it is, it both bears it and suffers no harm, through God's grace.' For, "we are pressed on every side," says he, "but not straitened." What is, "on every side?"

'In respect of our foes, in respect of our friends, in respect of necessaries, in respect of other needs, by them which be hostile, by them of our own household.' "Yet not straitened." And see how he speaks contrarieties, that thence also he may show the strength of God. For, "we are pressed on every side, yet not straitened," says he; "perplexed, yet not unto despair;" that is, 'we do not quite fall off. For we are often, indeed, wrong in our calculations , and miss our aim, yet not so as to fall away from what is set before us: for these things are permitted by God for our discipline, not for our defeat.'

2 Corinthians 4:9. "Pursued, yet not forsaken; smitten down, yet not destroyed." For these trials do indeed befal, but not the consequences of the trials. And this indeed through the power and Grace of God. In other places indeed he says that these things were permitted in order both to their own humble-mindedness, and to the safety of others: for "that I should not be exalted overmuch, there was given to me a thorn," [2 Corinthians 12:7] he says: and again, "Lest any man should account of me above that which he sees me to be, or hears from me;" and in another place again, "that we should not trust in ourselves:" [2 Corinthians 1:9] here, however, that the power of God might be manifested. Do you see how great the gain of his trials? For it both showed the power of God, and more disclosed His grace. For, says He, "My grace is sufficient for you." [2 Corinthians 12:9] It also anointed them unto lowliness of mind, and prepared them for keeping down the rest, and made them to be more hardy. "For patience," says he, "works probation, and probation hope." [Romans 5:4] For they who had fallen into ten thousand dangers and through the hope they had in God had been recovered , were taught to hold by it more and more in all things.

[AD 407] John Chrysostom on 2 Corinthians 4:8
The afflictions come not only from enemies but even from our own households and friends. These things are permitted by God, not for our defeat but for our discipline.

[AD 458] Theodoret of Cyrus on 2 Corinthians 4:8
If none of these things ever happened, the greatness of God’s power would never be revealed.