21 And Uzziah the king was a leper unto the day of his death, and dwelt in a several house, being a leper; for he was cut off from the house of the LORD: and Jotham his son was over the king's house, judging the people of the land.
When King Uzziah carried a censer and violently took on himself to sacrifice, against the law of God, and refused to submit or give place, despite the opposition of Azariah the priest, he was confounded by God’s indignation and defiled with the markings of leprosy on his forehead, branded by the Lord’s anger on that part of the body on which those who win the Lord’s favor are sealed.
Uzziah is described as at first having been righteous, and then it is related that he was lifted up in mind and dared to offer sacrifice to God himself, and his face became leprous in consequence. But Josephus carefully studied the additional comments of the expounders as well, and a Hebrew of the Hebrews as he was, hear his description of the events of those times. He tells: “Though the priests urged Uzziah to go out of the temple and not to break the law of God, he angrily threatened them with death unless they held their peace. And meanwhile an earthquake shook the earth, and a bright light shone through a breach in the temple and struck the king’s face, so that at once it became leprous. And before the city at the place called Eroga, the western half of the Mount was split asunder and rolling four stadia stopped at the eastern mountain, so as to block up the royal approach and gardens.” This I take from the work of Josephus on Jewish antiquities. And I found in the beginning of the prophet Amos the statement that he began to prophecy “in the days of Uzziah, king of Judah, two years before the earthquake.” What earthquake he does not clearly say. But I think the same prophet further on suggests this earthquake when he says, “I saw the Lord standing on the altar. And he said, Strike the altar, and the doors shall be shaken, and strike the heads of all, and the remnant I will slay with the sword.”Here I understand a prediction of the earthquake, and of the destruction of the ancient solemnities of the Jewish race and of the worship practiced by them in Jerusalem, the ruin that should overtake them after the coming of our Savior, when, since they rejected the Christ of God, the true High Priest, leprosy infected their souls, as in the days of Uzziah, when the Lord himself standing on the altar gave leave to him that struck, saying, “Strike the altar.”
In the midst of paradise God had planted the Tree of Knowledge to separate off, above and below, sanctuary from Holy of Holies. Adam made bold to touch and was smitten like Uzziah: the king became leprous, Adam was tripped. Being struck like Uzziah, he hastened to leave: both kings fled and hid, in shame of their bodies.
Remember Uzziah, how he entered the sanctuary; by seeking to seize the priesthood he lost his kingdom. Adam, by wishing to enrich himself, incurred a double loss. Recognize in the sanctuary the Tree, in the censer the fruit and in the leprosy the nakedness. From these two treasures there proceeded harm in both cases.
As, therefore, it was not lawful for one of another tribe that was not a Levite to offer anything or to approach the altar without the priest, so also do you do nothing without the bishop; for if anyone does anything without the bishop, he does it to no purpose. For it will not be esteemed as of any avail to him.… For as Uzziah the king, who was not a priest and yet would exercise the functions of the priests, was smitten with leprosy for his transgression; so every lay person shall not be unpunished who despises God, and is so mad as to affront his priests and unjustly to snatch that honor to himself: not imitating Christ, “who glorified not himself to be made an high priest” but waited till he heard from his Father, “The Lord swore and will not repent, You are a priest forever, after the order of Melchizedek.” If, therefore, Christ did not glorify himself without the Father, how dare anyone thrust himself into the priesthood who has not received that dignity from his superior and do such things that it is lawful only for the priests to do?
Neither do we permit the laity to perform any of the offices belonging to the priesthood, as, for instance, neither the sacrifice, nor baptism, nor the laying on of hands nor the blessing, whether the smaller or the greater, for “no one takes this honor to himself, but he that is called of God.” For such sacred offices are conferred by the laying on of the hands of the bishop. But a person to whom such an office is not committed but seizes on it for himself, he shall undergo the punishment of Uzziah.
Of Uzziah, the ancestor of this king of whom we have been speaking, himself also praised in all things by the witness of the Scripture, after great commendation for his virtue, after countless triumphs that he achieved by the merit of his devotion and faith, learn how he was cast down by the pride of vainglory. “And,” we are told, “the name of Uzziah went forth, for the Lord helped him and had strengthened him. But when he was made strong, his heart was lifted up to his destruction, and he neglected the Lord his God.” … You see how dangerous the successes of prosperity generally are, so that those who could not be injured by adversity are ruined, unless they are careful, by prosperity; and those who in the conflict of battle have escaped the danger of death fall before their own trophies and triumphs.
[AD 258] Cyprian on 2 Chronicles 26:16-23