14 Now we exhort you, brethren, warn them that are unruly, comfort the feebleminded, support the weak, be patient toward all men.
[AD 220] Tertullian on 1 Thessalonians 5:14
Where, then, do you show that they renewed the command to flee from city to city? In fact, it was utterly impossible that they should have laid down anything so utterly opposed to their own examples as a command to flee, while it was just from bonds, or the islands in which, for confessing, not fleeing from the Christian name, they were confined, they wrote their letters to the Churches. Paul bids us support the weak, but most certainly it is not when they flee.

[AD 407] John Chrysostom on 1 Thessalonians 5:14
Here he addresses those who have rule. Admonish, he says, "the disorderly," not of imperiousness, he says, nor of self-will rebuke them, but with admonition. "Encourage the fainthearted, support the weak, be longsuffering toward all." For he who is rebuked with harshness, despairing of himself, becomes more bold in contempt. On this account it is necessary by admonition to render the medicine sweet. But who are the disorderly? All those who do what is contrary to the will of God. For this order of the Church is more harmonious than the order of an army; so that the reviler is disorderly, the drunkard is disorderly, and the covetous, and all who sin; for they walk not orderly in their rank, but out of the line, wherefore also they are overthrown. But there is also another kind of evils, not such as this indeed, but itself also a vice, little mindedness. For this is destructive equally with sloth. He who cannot bear an insult is feeble-minded. He who cannot endure trial is feeble-minded. This is he who is sown upon the rock. There is also another sort, that of weakness. "Support the weak," he says; now weakness occurs in regard to faith. But observe how he does not permit them to be despised. And elsewhere also in his Epistles he says, "Receive those who are weak in the faith." [Romans 14:1] For in our bodies too we do not suffer the weak member to perish. "Be longsuffering toward all," he says. Even toward the disorderly? Yes, certainly. For there is no medicine equal to this, especially for the teacher, none so suitable to those who are under rule. It can quite shame and put out of countenance him that is fiercer and more shameless than all men.

[AD 407] John Chrysostom on 1 Thessalonians 5:14
If we are to hate ungodly and lawless men, we shall go on also to hate sinners. Thus, in regular succession, you will find yourself cut off from most of your brothers, indeed, from all of them. There is not one of them without sin. If it is our duty to hate the enemies of God, we would have to hate not only the ungodly but backsliders as well. Then we would be worse than wild beasts, shunning all and puffed up with pride, just like the Pharisee. Paul commanded us differently. “Admonish the disorderly, encourage the faint-hearted, support the weak, be long-suffering toward all.”

[AD 430] Augustine of Hippo on 1 Thessalonians 5:14
Of course, even good men can be sick, suffering from that disobedience which is the penalty of a primal disobedience which, therefore, is a wound or weakness in a nature that is good in itself. It is because of this wound that the good who are growing in grace and living by faith during their pilgrimage on earth are given the counsels, “Bear one another’s burdens, and so you will fulfill the law of Christ,” and elsewhere, “We exhort you, brothers, reprove the irregular, comfort the fainthearted, support the weak, be patient toward all men. See that no one renders evil for evil to any man.” … It is in this way that citizens of the City of God are given medicine during their pilgrimage on earth while praying for the peace of their heavenly fatherland. And, of course, the Holy Spirit is operative internally to give healing power to the medicine which is applied externally, for, otherwise, no preaching of the truth is of any avail. Even though God makes use of one of his obedient creatures, as when he speaks in human guise to our ears—whether to the ears of the body or to the kind of ears we have in sleep—it is only by his interior grace that he moves and rules our mind.

[AD 430] Augustine of Hippo on 1 Thessalonians 5:14
Hence, as far as concerns us, who are not able to distinguish those who are predestinated from those who are not, we ought on this very account to will all humanity to be saved. Severe rebuke should be medicinally applied to all by us that they neither themselves perish nor may be the means of destroying others. It belongs to God, however, to make that rebuke useful to them whom he himself has foreknown and predestinated to be conformed to the image of his Son. We do not abstain from admonishing for fear lest by rebuke a person should perish. So why do we not also rebuke for fear that one should rather perish by our withholding admonition? For there is no greater act of compassion on our part than when the blessed apostle says, “Rebuke those that are unruly; comfort the feeble-minded; support the weak; be patient toward all men. See that none render evil for evil.”

[AD 458] Theodoret of Cyrus on 1 Thessalonians 5:14
Let us then bravely bear the ills that befall us. It is in war that heroes are discerned; in conflicts that athletes are crowned; in the surge of the sea that the art of the helmsman is shown; in the fire that the gold is tried. And let us not, I beseech you, have concern for only ourselves, but let us rather look out for the rest, and that much more for the sick than for the whole, for it is an apostolic precept which exclaims, “Comfort the feeble-minded, support the weak.” Let us, then, stretch out our hands to them that lie low, let us tend their wounds and set them at their post to fight the devil. Nothing will so vex him as to see them fighting and smiting again.

[AD 542] Caesarius of Arles on 1 Thessalonians 5:14
It was to the laity and to women and not only the clergy that the apostle said, “Reprove the irregular, comfort the fainthearted, support the weak.” Provided that you are willing to rebuke one another in case of sin, the Enemy will be able to take you by surprise only with difficulty or not at all. If he does take you by surprise, the evil which was done is easily amended and corrected. Then is fulfilled in you what was written, “A brother who helps his brother will be exalted,” and again, “he who helps a sinner to be brought back from the misguided way will save his soul from death, and will cover a multitude of sins.”