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21 The salutation of me Paul with mine own hand.
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[AD 384] Ambrosiaster on 1 Corinthians 16:21
Paul makes it clear that he has written the subscript with his own hand.

Source: COMMENTARY ON PAUL’S EPISTLES
[AD 398] Didymus the Blind on 1 Corinthians 16:21
To avoid any suspicion of forgery, Paul signs the letter with his own hand.

Source: PAULINE COMMENTARY FROM THE GREEK CHURCH
[AD 407] John Chrysostom on 1 Corinthians 16:21
"The salutation of me Paul with my own hand;" intimates that the Epistle was composed with great seriousness; and therefore he added,

Source: Homily 44 on First Corinthians